2. Signaling Pathways
  3. GPCR/G Protein
  4. Angiotensin Receptor

Angiotensin Receptor

Angiotensin Receptor

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Angiotensin receptors are a class of G protein-coupled receptors with angiotensin II as their ligands. They are important in the renin-angiotensin system: they are responsible for the signal transduction of the vasoconstricting stimulus of the main effector hormone, angiotensin II. The AT1 and AT2 receptors have a similar affinity for angiotensin II, which is their main ligand. The AT1 receptor is the best elucidated angiotensin receptor. AT2 receptors are more plentiful in the fetus and neonate. Other poorly characterized subtypes include the AT3 and AT4 receptors.

Angiotensin Receptor Isoform Specific Products:

Angiotensin Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-111616
    GSK1820795A
    		Inhibitor 99.76%
    GSK1820795A, as a telmisartan analog, is a selective hGPR132a antagonist. GSK1820795A blocks activation of yeast cells expressing hGPR132a by N-acylamides. GSK1820795A is also a angiotensin II antagonists and partial PPARγ agonists (compound 38).
    GSK1820795A
  • HY-12765
    Losartan Carboxylic Acid
    		Antagonist 98.95%
    Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure.
    Losartan Carboxylic Acid
  • HY-P4685
    (Sar1,Ile4,8)-Angiotensin II
    		Agonist 98.69%
    (Sar1,Ile4,8)-Angiotensin II is a functionally selective angiotensin II type 1 receptor (AT1R) agonist. (Sar1,Ile4,8)-Angiotensin II potentiates insulin-stimulated insulin receptor (IR) signaling and glycogen synthesis. (Sar1,Ile4,8)-Angiotensin II potentiates insulin-stimulated phosphorylation of Akt and GSK3α/β.
    (Sar1,Ile4,8)-Angiotensin II
  • HY-P3137
    TRV056
    		99.91%
    TRV056 is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV056 is efficacious in stimulating cellular Gq-mediated signaling. TRV056 can be used to develop the Gq-biased AT1R agonists.
    TRV056
  • HY-15778A
    AVE 0991 sodium salt
    		Agonist 99.41%
    AVE 0991 sodium salt is a nonpeptide and orally active Ang-(1-7) receptor Mas agonist. AVE 0991 competes for high-affinity binding of [125I]-Ang-(1-7) to bovine aortic endothelial cell membranes with IC50 of 21 nM.
    AVE 0991 sodium salt
  • HY-117743
    Eprosartan
    		Antagonist 99.87%
    Eprosartan (SKF-108566J free base) is a selective, competitive, nonpeptid and orally active angiotensin II receptor antagonist, used as an antihypertensive. Eprosartan binds angiotensin II receptor with IC50s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively .
    Eprosartan
  • HY-P1564A
    [Sar1, Ile8]-Angiotensin II TFA
    		99.85%
    [Sar1, Ile8]-Angiotensin II (TFA) is a peptide that has multiple effects on vascular smooth muscle, including contraction of normal arteries and hypertrophy or hyperplasia of cultured cells or diseased vessels.
    [Sar1, Ile8]-Angiotensin II TFA
  • HY-P5123A
    Arg-Glu(edans)-Ile-His-Pro-Phe-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(dabcyl)-Arg TFA
    		Activator 98.75%
    Arg-Glu(edans)-Ile-His-Pro-Phe-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(dabcyl)-Ar TFA is a fluorogenic renin substrate  based on the N-terminal tetradecapeptide sequence of human angiotensinogen (hTDP).
    Arg-Glu(edans)-Ile-His-Pro-Phe-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(dabcyl)-Arg TFA
  • HY-P1415A
    Norleual TFA
    		Antagonist 99.32%
    Norleual TFA, an angiotensin (Ang) IV analog, is a hepatocyte growth factor (HGF)/c-Met inhibitor with an IC50 of 3 pM. Norleual TFA is an AT4 receptor antagonist and exhibits potent antiangiogenic activities.
    Norleual TFA
  • HY-13955S
    Telmisartan-d3
    		Antagonist 99.77%
    Telmisartan-d3 is the deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM[1][2].
    Telmisartan-d<sub>3</sub>
  • HY-P1839A
    Angiotensin I/II (1-5) (TFA)
    		99.52%
    Angiotensin I/II 1-5 TFA is a peptide that contains the amino acids 1-5, which is converted from Angiotensin I/II. Angiotensin I is formed by the action of renin on angiotensinogen. Angiotensin II is produced from angiotensin I. Angiotensin II has been investigated for the treatment, basic science, and diagnostic of Hypertension, Renin Angiotensin System, and Idiopathic Membranous Nephropathy.
    Angiotensin I/II (1-5) (TFA)
  • HY-A0250
    Tasosartan
    		Antagonist 99.07%
    Tasosartan is a long-acting angiotensin II (AngII) receptor antagonist.
    Tasosartan
  • HY-13948F
    Biotin-Ahx-Angiotensin II human
    		99.96%
    Biotin-Ahx-Angiotensin II human (Biotin-Ahx-Angiotensin II; Biotin-Ahx-Ang II; Biotin-Ahx-DRVYIHPF) is a biological active peptide. (biotin labeled HY-13948)
    Biotin-Ahx-Angiotensin II human
  • HY-P2381
    Sar-Arg-Val-Tyr-Val-His-NH2
    		Agonist
    Sar-Arg-Val-Tyr-Val-His-NH2 is a Gq-biased agonists, exhibits 10-fold larger molecular efficacies at the AT1R-Gq fusion protein compared with the AT1R-βarr2 fusion protein.
    Sar-Arg-Val-Tyr-Val-His-NH2
  • HY-12403A
    Talfirastide acetate
    		Antagonist 99.87%
    Angiotensin 1-7 (Ang-(1-7)) acetate is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 acetate inhibits purified canine ACE activity (IC50=0.65 μM). Angiotensin 1-7 acetate acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 acetate blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium.
    Talfirastide acetate
  • HY-14914S
    Azilsartan-d5
    		Antagonist 99.42%
    Azilsartan-d5 is the deuterium labeled Azilsartan(TAK-536), which is a specific and potent angiotensin II type 1 receptor antagonist.
    Azilsartan-d<sub>5</sub>
  • HY-P1815A
    C-Type Natriuretic Peptide (1-53), human TFA
    		99.00%
    C-Type Natriuretic Peptide (1-53), human TFA is the 1-53 fragment of C-Type Natriuretic Peptide. C-Type Natriuretic Peptide TFA is natriuretic peptide family peptide that is involved in the maintenance of electrolyte-fluid balance and vascular tone.
    C-Type Natriuretic Peptide (1-53), human TFA
  • HY-15834A
    Eprosartan mesylate
    		Antagonist 99.95%
    Eprosartan mesylate (SKF-108566J) is a selective, competitive, nonpeptid and orally active angiotensin II receptor antagonist, used as an antihypertensive. Eprosartan mesylate binds angiotensin II receptor with IC50s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively.
    Eprosartan mesylate
  • HY-P1519B
    Brain Natriuretic Peptide (1-32), rat acetate
    		98.66%
    Brain Natriuretic Peptide (1-32), rat acetate (BNP (1-32), rat acetate) is a 32 amino acid polypeptide secreted by the ventricles of the heart in response to excessive stretching of heart muscle cells (cardiomyocytes).
    Brain Natriuretic Peptide (1-32), rat acetate
  • HY-13948F1
    Angiotensin II human, FAM-labeled
    		Activator 99.53%
    Angiotensin II human, FAM-labeled (Angiotensin II, FAM-labeled ; Ang II, FAM-labeled ; DRVYIHPF, FAM-labeled) is a biological active peptide. (FAM labeled HY-13948)
    Angiotensin II human, FAM-labeled
Cat. No. Product Name / Synonyms Application Reactivity
Angiotensin Receptor Isoform Comparison

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